Hypersensitivity Reaction to Carboplatin in Gynecologic Cancer: A Case Report and a Review of the Literature

A combination chemotherapy of paclitaxel plus carboplatin (TC) is the most frequently used regimen for gynecological malignancies. As long as it effective, a carboplatin-containing every relapse. This implies that number platinum administrations and frequency hypersensitivity reaction (HSR) increase prognosis improves. When patient develops HSR to carboplatin, we have three options: 1) desensitizing continuing use 2) switching other drugs, or 3) changing non-platinum drug. Here report an experience in with recurrent uterine carcinosarcoma. The was treated by surgery TC therapy initially, resulting no residual disease. relapsed 18 months after completion first-line again second-line. An occurred at 10th cycle total. We replaced cisplatin. including cisplatin adriamycin repeated without further HSR. reviewed literature regarding this paper summarize management dealing it.